Adtralza^® works with your immune system to block some of the processes that can cause inflammation and other symptoms of atopic dermatitis.^1-3

The active substance in Adtralza^® is tralokinumab. Adtralza^® is available in two injection formats:

• A pre-filled syringe containing 150 mg of tralokinumab in 1 ml solution for injection.
• A pre-filled injection pen containing 300 mg of tralokinumab in 2 ml solution for injection.

Your care team will help you choose the format that best suits your needs, as well as how much Adtralza^® you will require and for how long.

Inject Adtralza^® yourself only after you have been trained by your doctor or nurse. A caregiver may also give you your Adtralza^® injection after proper training.

The recommended first dose of Adtralza^® is 600 mg (four 150 mg injections with the pre-filled syringe and two 300 mg injections with the pre-filled pen). The first dose is followed by 300 mg (two 150 mg injections with the pre-filled syringe and one 300 mg injection with the pre-filled pen) given every 2 weeks. Based on how well the medicine works, your doctor may decide that you can have a dose every 4 weeks.

If you miss injecting a dose at the right time, inject Adtralza^® as soon as possible. Then the next dose should be injected at the regular scheduled time.

If you use more of this medicine than you should or the dose has been given too early, talk to your doctor, pharmacist or nurse.

Adtralza^® can be injected into your stomach area (abdomen), your thighs or your upper arm. To inject into your upper arm, you will need a caregiver to give you the injections. View the instruction videos for step-by-step guidance on how to inject Adtralza^® with both the pre-filled syringe and pre-filled pen formats.

Store Adtralza^® in the fridge between 2º C and 8º C. Do not freeze. Go to Adtralza^® contents and storage for more details.

If necessary, Adtralza^® pre-filled syringes may be kept at room temperature up to 25° C in the original package for a maximum of 14 days. Do not store above 25° C. Throw the medicine away if it is not used within 14 days of storage at room temperature.

If necessary Adtralza^® pre-filled pens may be kept at room temperature up to 30° C in the original package for a maximum of 14 days. Do not store above 30° C. Throw the medicine away if it is not used within 14 days of storage at room temperature.

Ask your doctor, pharmacist or nurse how to throw away medicines you no longer use. Do not throw them away via household waste.

If you are travelling up to 14 days. you can remove your Adtralza^® pre-filled syringes or pens from the fridge on the day of travel and they can be kept at room temperature (25° C for pre-filled syringes and 30° C for pre-filled pens) for up to 14 days. If you need to permanently remove the pack from the fridge, write down the date of removal on the pack, and use Adtralza^® within 14 days. Ask your care team for advice if you plan to be away from home for more than 14 days.

You can stay on track using your specially designed Adtralza^® treatment diary available with your Adtralza^® welcome pack. You can also keep track by adding reminders on your phone or making notes in your calendar – whatever works best for you.

Like all medicines, Adtralza^® can cause side effects, although not everybody gets them. The most commonly reported side effects with Adtralza^® are joint pain, headache, tiredness, diarrhoea, common cold and mouth or throat pain.

Tell your doctor if you have any new or worsening eye problems, including eye pain or changes in vision.

Tell your doctor if you have diarrhoea, gas, upset stomach, greasy stools or dehydration, which could be signs of a parasitic infection. If you live in a region where these infections are common or if you are traveling to such a region, tell your doctor.

You can find more information about side effects in the Adtralza^® Patient Information Leaflet that comes in the pack.

Rarely, allergic reactions may occur with Adtralza^®. See What you should know before taking Adtralza^® for more details. If you develop an allergic reaction, stop using Adtralza^® and talk to your doctor right away.

Everyone is different and results from Adtralza^® treatment may vary from patient to patient. Some patients may see results after a few weeks, some may not see results at all, and others may need longer than a few weeks.^4-6

With the pre-filled syringe, the first dose of Adtralza^® (four 150 mg injections) is followed by two 150 mg injections every 2 weeks.

With the pre-filled pen, the first dose of Adtralza^® (two 300 mg injections) is followed by one 300 mg injection every 2 weeks.

Based on your response, your doctor will decide how much Adtralza^® you need (which could reduce dosing down to every 4 weeks) and for how long.

You should not stop OR START taking any other atopic dermatitis medicines without first discussing this with your doctor. Adtralza^® can be used with or without other eczema medicines.

Atopic dermatitis is a chronic disease that can be managed but not cured,⁷ and because everyone responds differently to treatment, subsequent flare-ups cannot be ruled out. Ask your care team for more information specific to your individual case.